Эпидемиология

Пособие составлено на основании действующих нормативно-правовых документов, регламентирующих проведение профилактики внутрибольничных инфекций в учреждениях здравоохранения. В пособии представлены общие вопросы инфектологии – понятия инфекционного и эпидемиологического процессов, основные сведения по инфекционным заболеваниям, являющиеся наиболее частой причиной профессиональной заболеваемости. В конце пособия представлены материалы для самоконтроля знаний по санитарно-противоэпидемическому режиму. Пособие предназначено для студентов и преподавателей профессиональных образовательных учреждений, медицинских работников учреждений здравоохранения, в том числе осваивающих дополнительные образовательные программы по укрупненным группам специальностей: «Клиническая медицина», «Науки о здоровье и профилактическая медицина», «Сестринское дело».

Монография посвящена новому заболеванию, которое стало известно как COVID-19. Авторам принадлежит приоритет (как минимум в России) в описании острого коронавирусного миокардита с выделением РНК вируса из ткани миокарда, сделанного на основании анализа аутопсийного материала. Первые главы содержат анализ литературы относительно патогенеза поражения сердца при новой коронавирусной инфекции, а также описание первых и последующих случаев миокардита при COVID-19 в зарубежных публикациях с подробным изложением собственных исследований морфологии и проявлений этого миокардита. Отдельная глава посвящена вопросам иммунных, воспалительных и аутоиммунных реакций. Несмотря на большое количество публикаций, посвященных постковидному синдрому, анализа случаев постковидного миокардита в литературе практически нет; хотя он составляет значительную долю среди современных миокардитов. Это требует выработки особых подходов к лечению, которые также отражены в монографии. Наконец, отдельного обсуждения потребовали вопросы присоединения постковидного миокардита к другим болезням миокарда (первичным кардиомиопатиям), его возможная роль в прогрессировании и даже индукции амилоидоза, особенности ведения больных с нековидным миокардитом с учетом проводимой им иммуносупрессивной терапии, а также случаи миокардита, обусловленные вакцинацией вакцинами против коронавируса либо развившиеся после вакцинации у ранее переболевших. Все главы монографии написаны на основании собственного клинического материала, дополненного прижизненным морфологическим исследованием миокарда (эндомиокардиальной биопсией). Для практикующих врачей – кардиологов, терапевтов, патологоанатомов, а также ординаторов и аспирантов соответствующего профиля.

[b]Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences[/b] [b]A practical guide to the use of basic principles of experimental design and statistical analysis in pharmacology [i]Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences[/i] provides clear instructions on applying statistical analysis techniques to pharmacological data. Written by an experimental pharmacologist with decades of experience teaching statistics and designing preclinical experiments, this reader-friendly volume explains the variety of statistical tests that researchers require to analyze data and draw correct conclusions. Detailed, yet accessible, chapters explain how to determine the appropriate statistical tool for a particular type of data, run the statistical test, and analyze and interpret the results. By first introducing basic principles of experimental design and statistical analysis, the author then guides readers through descriptive and inferential statistics, analysis of variance, correlation and regression analysis, general linear modelling, and more. Lastly, throughout the textbook are numerous examples from molecular, cellular, [i]in vitro[/i], and [i]in vivo[/i] pharmacology which highlight the importance of rigorous statistical analysis in real-world pharmacological and biomedical research. This textbook also: Describes the rigorous statistical approach needed for publication in scientific journals Covers a wide range of statistical concepts and methods, such as standard normal distribution, data confidence intervals, and post hoc and a [i]priori[/i] analysis Discusses practical aspects of data collection, identification, and presentation[/i] Features images of the output from common statistical packages, including GraphPad Prism, Invivo Stat, MiniTab and SPSS [i]Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences [/i]is an invaluable reference and guide for undergraduate and graduate students, post-doctoral researchers, and lecturers in pharmacology and allied subjects in the life sciences.

[b]An introduction to state-of-the-art modeling and simulation approaches for social and economic determinants of population health[/b] [i]New Horizons in Modeling and Simulation for Social Epidemiology and Public Health[/i] offers a comprehensive introduction to modeling and simulation that addresses the many complex research questions in social epidemiology and public health. This book highlights a variety of practical applications and illustrative examples with a focus on modeling and simulation approaches for the social and economic determinants of population health. The book contains classic case examples in agent-based modeling (ABM) as well as essential information on ABM applications to public health including for infectious disease modeling, obesity, and tobacco control. This book also surveys applications of microsimulation (MSM) including of tax-benefit policies to project impacts of the social determinants of health. Specifically, this book: Provides an overview of the social determinants of health and the public health significance of addressing the social determinants of health Gives a conceptual foundation for the application of ABM and MSM to study the social determinants of health Offers methodological introductions to both ABM and MSM approaches with illustrative examples Includes cutting-edge systematic reviews of empirical applications of ABM and MSM in the social sciences, social epidemiology, and public health Discusses future directions for empirical research using ABM and MSM, including integrating aspects of both ABM and MSM and implications for public health policies Written for a broad audience of policy analysts, public planners, and researchers and practitioners in public health and public policy including social epidemiologists, [i]New Horizons in Modeling and Simulation for Social Epidemiology and Public Health[/i] offers a fundamental guide to the social determinants of health and state-of-the-art applications of ABM and MSM to studying the social and economic determinants of population health.

[b]DEMYSTIFYING RESEARCH FOR MEDICAL & HEALTHCARE STUDENTS All healthcare students need to understand research methods to be able to understand research articles and to actively engage in research where necessary. Most clinical programs include research training within their courses, and many students are required to undertake an assessed research project—both at undergraduate and postgraduate levels. Breaking down the jargon barriers of research methods, and designed for those new to the world of research, [i]Demystifying Research[/i] is a straightforward and highly accessible guide to fundamental research methods, approaches, and skills. This student-friendly resource describes quantitative and qualitative research approaches, mixed research methods, research ethics and governance, research skills and more. Step-by-step, students learn to appraise research in scholarly articles, design a project, and conduct research in the lab, in clinical practice, and other real-life situations. Technical jargon and classic research are explained in plain English, while relevant theory is illustrated through relatable examples of research in practice. Designed to make learning about research easy, this valuable guide: Explains basic research methods in a direct and engaging style Breaks research methods down into manageable, easy-to-digest pieces Defines what research is, and provides an overview of its methods and methodologies Covers all key areas of research, including observational and experimental approaches, and clinical trials Includes real-life examples of successful student research projects Features a companion website containing lecture slides available to download in PowerPoint [i]Demystifying Research [/i]is a must-have for undergraduate and postgraduate medical, nursing, other healthcare and social sciences students, as well as professionals looking to refresh their knowledge.